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- Nula (5yr old English Cocker Spaniel)
Hi all,
Nula was rushed to the emergency vets on Easter Sunday after getting suddenly lethargic with very pale gums. She stayed in over night on a cold drip because her temperature was really high. On Monday afternoon we bought her home after a ‘confident’ diagnosis of AIHA. Her PCV was 22 and scans showed nothing suspicious that could be causing it. She’s home now but very tired and she’s now on prednisolone. Her temperature this morning is back in the normal range. Waiting for a Coomes test to come back tomorrow or Thursday. Does anyone have anything to suggest to help her through this? I’m feeling out of my depth and I can’t lose her!! We know the lady who has Nula’s littermate and so anything known about genetics or anything I should be telling her to watch out for? Any help would be greatly appreciated! Thank you for reading xxxxx

Hi Ruth, I’m so sorry you’ve been thrown into the deep end of this pool. It’s a terrifying disease in that it seems one day our dogs are okay and the next they’re in emergency.
If you have details of any tests run, post them here. There are some fabulous people here who understand the test results and can help you understand them – I’m not one of them.
Prednisone is the major drug used to treat AIHA. It’s a horrible drug in that it has heaps of side effects, BUT it’s a life saver and we’ve all come to respect it. Some of the side effects can be scary. – panting, excessive drinking and peeing. They feel very hot and if you always had a cuddling dog, you may find that Nula will be more comfortable on a cool floor – that was one of the hardest things I found. Keep Nula quiet for now. She’ll be feeling very tired because of the low red blood. One thing though, she’s not in pain.
When do you go back for testing again. A PCV of 22 isn’t critically dangerous – so that’s good, but it’s important to make sure that the number doesn’t drop. In the early days, it’s important to be checked every few days. Bingo was tested 3 times a week when he first came out of hospital until stable and then the tests started to move further apart.
Ask anything at all. Someone has been through what you’re going through. The people here are really really wonderful. We all know what it’s like to be terrified because our dog or cat is suddenly so very sick.
My very best,
Vally & Bingo (diagnosed Nov 2011 – in remission)
Ruth,
Hello and welcome.
I am very sorry to hear about Nula becoming so very ill. I understand completely how confused and frightened you are. I remember feeling the very same way when Chance was sick.
We are here to help you especially in these first hours and days. It is impossible for you, on your own, to learn everything you need to know in order to make good decisions about Nula’s care. So please take a deep breath and let us do some of the heavy lifting for you.
You are clever to think about Nula’s littermate and it’s even more important to think about your breeder’s help right now too. If you contact them they may agree that your breed has a greater risk of developing this condition than some other breeds.
But it often takes a trigger or even several to start this process. Some common triggers are recent vaccinations, serious viral infections, a tendency towards allergies. Others are environment like tick diseases, bee stings, ingestion of garlic, onions, rat poisons and certain coins. Age, sex and diet also play a role. Females are more at risk than males .
You have taken the very best first steps an owner can, get to the vet quickly and get Nula cared for in emergency.
Now I would like you to sit down and put together a list of anything that you think she may have been exposed to in the last few weeks. Easter is a time of family gathering. Is it possible she was given food with onions in it? Did she travel somewhere and go outside in a new place that might have ticks or have dirty muddy water? Has she recently been vaccinated? Would a neighbor have put out rat poison?
Get copies of all the lab work that your vet has done. This belongs to you, you paid for it. Even if you don’t understand it, we do and we can help you read it.
Make a medication list and write down the names of all the medicine, dosages and times given. Make a list of any supplements she already receives or things that your vet may have given you. Does she take heartworm medication and do you use any tick or flea preventative?
Post this information here. Once we have a good idea of what is being done, we can guide you with what will happen next and make suggestions. We are not vets, but every one of has gone through this frightening experience with our dogs. Some of us were successful and some have lost their companion. But they are all dedicated to help you through this to the best of their ability.
my best
patrice
I forgot, is Nula on aspirin and stomach protection? They are very important. If not, please ask because blood clots are one of the biggest killers in this disease. The prednisone is very hard on the stomach, that’s why stomach protection is recommended.
Anyway if you can list the drugs that you’ve been given for Nula.
Again, very best. Vally & BIngo
Hi Ruth, and welcome, although I am very sorry to hear about your circumstances.
I’m the resident cat owner on the site, and went through this with my girl a few months ago, with a similar situation of a seemingly sudden onset. It’s a terrifying time and I know you will have a lot of questions and worries.
Vally and Patrice have already given you excellent advice, and I totally agree with what they have said. As Patrice has mentioned, it will be helpful if you can provide us with more information when possible. When does your vet plan to recheck Nula’s PCV? Personally I would want it testing every couple of days at the moment. How did your vet arrive at the diagnosis? Was a bone marrow biopsy taken? Have they told you whether it is regenerative or non-regenerative?
As Vally said, it is extremely important that Nula is given an anticoagulant to prevent blood clotting, as well as a stomach protectant.
Has Nula been well until now? Has she suffered any other unusual reactions or illnesses?
It also seems that Prednisolone, whilst very beneficial, may not be enough on its own to halt the AIHA. Other immunosuppressant drugs, like cyclosporine or azathioprine may be added in.
Keeping Nula nourished may be challenging, as they will often lose their appetite with this condition. Hopefully she is eating well, but let us know if not and I’m sure we can help with some suggestions. As Vally mentioned, she will be probably be quite lethargic at the moment and will be very tired, as well as likely feeling hot and drinking a lot. You can help by keeping her water very close to her bed etc, limiting the energy she has to use.
As for littermates – I was informed by our specialists that there is no evidence of a genetic component, and that Molly’s sister was not at any great risk. However, there is evidence of certain dog breeds being slightly predisposed to AIHA, so I would think that contacting the littermates’ owner/breeder would be a good idea.
I’m sorry for so many questions, and please don’t worry if you can’t answer them all. I know you must be frantic right now, but I am pleased you have found this site and hope that we can support you through this.
Very best wishes to you and Nula,
Mary & Mable x
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Hello Ruth. I am sorry I am just now seeing this. Bless your heart. We all know – have been right where you are right now. I was a deer in the headlights, so to speak – had never, ever heard of this terrible stinking disease. I was in tears and beside myself. But these are the people that got me through it AND helped save Sadie’s life. So for us all – it’s pay-it-forward. So sorry for the reason, but so glad you found the forum. We’re here for you and Nula, all the way.
When Sadie came down with AIHA in March of 2013 (her story and the others are here, will help to read them), her PCV was 22 also. That is not horribly low, so that was a good thing for Sadie and I can’t help but think it’s a good thing for Nula too. Many dogs that come down with AIHA/IMHA have much, much lower PCV’s.
About siblings: my daughter has Sadie’s sister, Sophie, (cocker spaniels) and she is the healthy – NO problems at all, thank goodness. We think Sadie got into some pesticides that had been sprayed from the shore on to the lake in back of our house to kill foliage – copper being one of the ingredients (very toxic to dogs). Sadie had played down near the shore – I had thought nothing of it at the time. Four days later, she collapsed. I should have known, as many of the fish died – stupid humans.
To give you hope, Sadie is good today, as are many of the dogs that get AIHA/IMHA. This disease CAN be beat! Please stay with us. You cannot ask too many questions and no question is trivial. And as Vally and Patrice said, post Nula’s blood work here. Those that know much more than I do will help with that.
As has been mentioned, and what I just didn’t get at first although they tried to tell me, is that AIHA dogs on these necessary drugs, need protection for their tummies, liver and an anti-clotting (already mentioned), as these drugs will play havoc on their bodies. Nula will most likely be put on an additional immune suppressant – she will need protection, none the less. I am thinking she about 40 pounds or so?
Anti-clotting medication: Sadie is on Clopidogrel (75 mg / 1/2 tab daily). Clopidogrel is the generic form of human Plavix. She’s had no problems, no clotting.
Tummy protection: Nula will need something for her tummy. Sadie was on Sucralfate, prescription only, which is a great gastrointestinal medication for prevention of ulcers. But I now give her a half/tab of a 10mg Pepcid, which is, of course, over the counter. I also give her slippery elm (there is a cocktail – I can send the recipe, if you like).
Liver Protection: Nula will need liver protection from the needed medications. Sadie was on Denamarin, prescription only, but it is very processed and since Sadie relapsed (don’t worry – our fault, poor baby – we weaned her too fast – we were back at square one, darn it) I opted for the more natural approach and started using milk thistle (I use HerbPharm liquid, buy from Amazon or straight from their website) and CellFood SAM-e (Amazon). Denamarin’s main ingredients are milk thistle and SAM-e.
I also, still, keep on hand, Cerenia, for Sadie, just in case she has a bad night with her tummy. It is mainly used in dogs for vomiting (which Sadie NEVER did, thank goodness). Cerenia is actually for motion sickness, but for some reason it is the ‘miricle pill’ for their tummies too. I would have some on hand – because when you need it, it may be the middle of the night. You should see relief not long after administering. It’s expensive and only comes four to a box – but it’s well worth having on hand. Ask your vet about this too.
Okay you all – I am sure I’m missing something – supplements needed?
This disease is a roller coaster. I remember writing daily, thinking I had it down and wam – I would be at a loss. That happened much – so don’t feel alone, because it can do that to you. Hang in there – and remember – take one day at a time. It’s still my motto. Of course, we’re all super paranoid AIHA fur parents here on this forum, but that’s a good thing – because we love our precious pups so much – as you love Nula.
You did GREAT getting Nula to the vet so fast. I truly think that helps so much. And as Patrice said, get a copy of Nula’s bloodwork – every time. Don’t pay until they give it to you! ;)
Also, you will end up giving medication that can’t be given with anything else, has to be given an hour before eating, an hour after eating, or with food, etc. Vally made a medication chart and sent it to me (THANK YOU DEAR FRIEND) and it REALLY helped. I still use it – my medication bible for Sadie. I can send you mine, if you like or Vally will send it to you.
Oh and one more thing – this was told to me early on (THANK YOU SHEENA) – try, as hard as it may be, to be calm around Nula. They pick up on your angst and right now, as mentioned, it’s best to keep her quiet and calm.
Please don’t be overwhelmed by this post.
Stay with us – we’re here for you – always.
Love and hugs, Linda and Sadie
Hi Ruth
It’s lovely that you have found us, but I’m so very sorry that poor Nula has this nasty disease. We were all shocked when we heard our dogs or cats had been diagnosed with AIHA/IMHA, so understand exactly what you are going through. There is always great advice from everyone on here & if you have any questions at all, just ask away.
As Vally said, prednisone has horrible side effects, but it is an absolutely essential drug to beat this disease. Your vet will probably add a long-acting immuno-suppressant to the treatment. Along with Patrice, Linda & Mary, I can only emphasise that the RIGHT treatment protocol is essential. Here are the vital bits & the links to our information;
High dose prednisone – see
https://www.secondchanceaihadogs.com/AIHA_Terms/prednisone/
Long-acting immuno suppressant e.g. azathioprine, cyclosporine
https://www.secondchanceaihadogs.com/AIHA_Terms/azathioprine/
https://www.secondchanceaihadogs.com/AIHA_Terms/cyclosporine/
Anti-clotting medication – please – this is very important – see https://www.secondchanceaihadogs.com/AIHA_Terms/abnormal-clotting/
Tummy protection (e.g. sucralfate/pepcid)
Liver protection (milk thistle) as these drugs affect the liver.
Possibly antibiotics for any infection (I say this as her temperature was high) & maybe other drugs too.
I hope I haven’t overdosed you with information!! You certainly have a lot to read now.
Most of all, Ruth, keep on fighting for Nula. This disease can be beaten. My dog Worzel was diagnosed with a rare form of AIHA in Dec 2012. He was pretty exceptional as he didn’t need anti-clotting medication, but the vast majority do. His blood test yesterday shows he has made a good recovery (crossing everything for it to continue!), so I hope this makes you feel happier that Nula CAN get better.
It is really useful for us to have as much information as possible. You are doing an amazing job & thank goodness you saw that something was wrong so quickly. Please let us know how Nula is doing & what we can do to help you.
Sending you & Nula all our best wishes
Sheena, Worzel & Ollie
Thank you all SO MUCH for your replies!! It’s giving me a lot of comfort right now! I’m afraid it’s not good news today. Nula had a bad night, threw up everything she ate yesterday and her gums went almost white. Rang emergency vets and they referred her to Dick Whites (our local specialist vets). Got her there and she had to be carried in. She’s having a blood transfusion and various tests. She’s going to be there several days even if she does well. House very empty without her. Absolutely gutted! She was picking up yesterday