NexGard

[admin]

Hi all

NexGard has just become available in our vets in France & they are keen for me to use it because of Worzel not having vaccinations. Do any of you use it or have experience of using it? One of the junior vets checked with the drug rep to make sure it would be OK for Worzel & it’s “not a problem” as far as AIHA/IMHA is concerned according to the drug company. Of course, I never believe anything until I look at the research myself, so I checked out the following:

http://www.merial.com/EN/PressRoom/PressRelease/Pages/NEXGARD_en.aspx

http://www.fda.gov/downloads/AnimalVeterinary/Products/ApprovedAnimalDrugProducts/FOIADrugSummaries/UCM377867.pdf

It looks very effective & has no known side effects other than vomiting that I can see. I can live with that if it prevents what happened to Worzel with his ehrlichiosis (and all those other tick/flea nasties). It more importantly has no known effect on blood components according to the research. I would still like your opinions please before I decide to use it though, being a member of the crazy, paranoid, worry guts club.

They also can now provide a French version of the Snap Test for 50 Euros (EACH!), which seems very expensive to me. How much do you pay in the USA?

Any information you could give me would be appreciated – Thank you!

Sheena, Worzel & Ollie xxxx

[Tamara]

Hi Sheena, I can’t help about Nexgard, but I can tell you what I paid for Ashki’s tick/flea borne disease tests.  For an Acuplex Snap Test (HW/Tick panel) is $44US and for a Fastpanel PCR Canine Tickborne it was $263US.

I can get a list of the diseases tested for each if you’d like, just let me know.

Tamara and Ashki xoxoxox

[admin]

Hi Sheena.  I have not heard of it, but looked it up for the USA and found that it is made by the makers of Frontline Plus, which I have heard of, of course.

http://www.nexgardfordogs.com/Pages/index.aspx?utm_source=bing&utm_medium=cpc&utm_term=NexGard%20usa&utm_campaign=BR_Nexgard_Nexgard_Exact&utm_content=cWV2ETfw|4259302981

And in the FAQ, there was this:  Can I use it if my dog is on medication?  I could not copy and paste, as it would disappear when I tried.  But look at it under FAQ.

It seems to have been introduced in December 2013.  I am still leery, because they really pushed Trifexis as being the new ‘super’ flea/tick med and so many dogs (perhaps even Sadie, who knows – she was on it, but I had stopped months before she collapsed) became and are still becoming sick from the product.  I have heard, heard mind you, that there may be a recall on Trifexis.  Until it happens though, who knows.

I also read some reviews on 1-800-petmeds.  After reading ALL the reviews, I’m still not sure about using it.  Like I said, since it’s been out for about

In a well-controlled field study, NexGard was used concomitantly with other medications, such as vaccines, anthelmintics, antibiotics (including topicals), steroids, nonsteroidal anti-inflammatory drugs (NSAIDs), anesthetics, and antihistamines.

 

In a well-controlled field study, NexGard was used concomitantly with other medications, such as vaccines, anthelmintics, antibiotics (including topicals), steroids, nonsteroidal anti-inflammatory drugs (NSAIDs), anesthetics, and antihistamines.

Sadie’s vet is due to call today, so I will ask her about it and let you know her thoughts.  Anyone else know anything?  Wouldn’t it be wonderful if there IS a flea/tick preventative that our dogs could take.

Is Ollie still doing well on the gelatin and GLM’s?  Give both Worzel and Ollie huge hugs.  Love, Linda & Sadie

[admin]

Thanks Tamara – much appreciated! So price looks OK, actually – it’s all the tick/flea diseases we have here in France I was quoted for. Your PCR tests are very cheap compared to here. Interesting!

[admin]

Hi Linda

Thank you for that – yes it’s the Frontline lot – they also do Certifect which is more effective but cannot be used for some breeds as it can cross the blood-brain barrier, e.g. Border Collies. I have never used that either because of that fear. I have e-mailed the specialist on the NexGard  & am waiting for an answer – he is always a busy boy, so I won’t hold my breath! I would appreciate you asking your vet – any information is gratefully received. I saw the FDA licence was Sept 2013, so it’s fairly new over there too & it would be good if something actually was completely safe & worked for us all.

Ollie is doing well thanks, but is doesn’t like the gelatin in his food. I am ordering capsules next time to pop down his throat to save the subterfuge we have to do to hide it – he thinks we’re trying to poison him & is suspicious of his meals now!

Love & cuddles to you & the Birthday Girl

Sheena, Worzel & Fuss Pot xxxx

[Vally]

Linda, here the Trifexis is called Panoramis, so people here don’t even know there’s possibly a huge problem with it. Terrible.

[Vally]

Now Fuss Pot, mum is NOT trying to poison you.

Aren’t they funny.  I’m glad Bingo is a scoffer.  Will scoff anything and everything down (except zucchini).

Love Vally & Scoffer

[Patrice]

“NEXGARD kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis), and the treatment and control of American Dog tick (Dermacentor variabilis) infestations in dogs and puppies 8 weeks of age and older, weighing 4 pounds of body weight or greater, for one month.”

“Mode of Action:
Afoxolaner is a member of the isoxazoline family, shown to bind at a binding site to
inhibit insect and acarine ligand-gated chloride channels, in particular those gated
by the neurotransmitter gamma-aminobutyric acid (GABA), thereby blocking pre- and post-synaptic transfer of chloride ions across cell membranes. Prolonged afoxolaner-induced hyperexcitation results in uncontrolled activity of the central nervous system and death of insects and acarines. The selective toxicity of afoxolaner between insects and acarines and mammals may be inferred by the differential sensitivity of the insects and acarines’ GABA receptors versus mammalian GABA receptors.”
“Adverse Reactions:
In a well-controlled US field study, which included a total of 333 households and 615 treated dogs (415 administered afoxolaner; 200 administered active control), no serious adverse reactions were observed with NEXGARD.

Over the 90-day study period, all observations of potential adverse reactions were recorded. The most frequent reactions reported at an incidence of > 1% within any of the three months of observations are presented in the following table. The most frequently reported adverse reaction was vomiting. The occurrence of vomiting was generally self-limiting and of short duration and tended to decrease with subsequent doses in both groups. Five treated dogs experienced anorexia during the study, and two of those dogs experienced anorexia with the first dose but not subsequent doses”

“Use with caution in dogs with a history of seizures”

“A structurally unique isoxazoline class compound, A1443, exhibits antiparasitic activity against cat fleas and dog ticks comparable to that of the commercial ectoparasiticide fipronil. ”

Here are my thoughts. Nexgard is taken by mouth so that makes it systemic. So that is a big difference between it and the similar pesticide fipronil used in Frontline. Frontline works by distributing the pesticide in the oil glands of the skin and is not systemic.

Both pesticides act on neurotransmitters in fleas and ticks to cause nervous system disruption that leads to death. Pesticides of this nature are considered safe to mammals because their nervous systems are so different. However some breeds seem more sensitive because of a genetic difference. All vets should know which breeds these are and should exercise caution when prescribing this pesticide or any other.

While Nexgard claims it is effective against the American Dog Tick, that would, in a sense make it seem to be ineffective against the Deer Tick or the Lone Star Tick because  the literature does not mention them. Is this true or not? Is it possible they did not mention this because they didn’t test for these ticks? American Dog Ticks are now carrying some diseases but my fear where I live is the Deer Tick.  That’s the one that carries some nasty diseases.

Fleas are not life threatening, ticks can be. I am reluctant myself to put something inside my dog in order to get rid of fleas. I feel more comfortable putting Frontline on them and being vigilant about checking them.

I do use other protection that is extremely effective and safe. Permethrin is a  man-made derivative of Chrysanthemum flower extract that is impregnated into clothing fibers. It usually lasts through up to 70 washings. And before you ask, no it can’t weep onto the skin or into water. They have tested this significantly since it is used for American Military clothing and have found that the only way Permethrin leaves the clothing is via dryer lint. So both of us have head to toe ExOfficio clothing and I put big red bandannas on the dogs. Search for Doggles Insect Shield Bandana, but there are many brands.
my best
patrice

[admin]

Hi all

NexGard has just become available in our vets in France & they are keen for me to use it because of Worzel not having vaccinations. Do any of you use it or have experience of using it? One of the junior vets checked with the drug rep to make sure it would be OK for Worzel & it’s “not a problem” as far as AIHA/IMHA is concerned according to the drug company. Of course, I never believe anything until I look at the research myself, so I checked out the following:

http://www.merial.com/EN/PressRoom/PressRelease/Pages/NEXGARD_en.aspx

http://www.fda.gov/downloads/AnimalVeterinary/Products/ApprovedAnimalDrugProducts/FOIADrugSummaries/UCM377867.pdf

It looks very effective & has no known side effects other than vomiting that I can see. I can live with that if it prevents what happened to Worzel with his ehrlichiosis (and all those other tick/flea nasties). It more importantly has no known effect on blood components according to the research. I would still like your opinions please before I decide to use it though, being a member of the crazy, paranoid, worry guts club.

They also can now provide a French version of the Snap Test for 50 Euros (EACH!), which seems very expensive to me. How much do you pay in the USA?

Any information you could give me would be appreciated – Thank you!

Sheena, Worzel & Ollie xxxx

[Tamara]

Hi Sheena, I can’t help about Nexgard, but I can tell you what I paid for Ashki’s tick/flea borne disease tests.  For an Acuplex Snap Test (HW/Tick panel) is $44US and for a Fastpanel PCR Canine Tickborne it was $263US.

I can get a list of the diseases tested for each if you’d like, just let me know.

Tamara and Ashki xoxoxox

[admin]

Hi Sheena.  I have not heard of it, but looked it up for the USA and found that it is made by the makers of Frontline Plus, which I have heard of, of course.

http://www.nexgardfordogs.com/Pages/index.aspx?utm_source=bing&utm_medium=cpc&utm_term=NexGard%20usa&utm_campaign=BR_Nexgard_Nexgard_Exact&utm_content=cWV2ETfw|4259302981

And in the FAQ, there was this:  Can I use it if my dog is on medication?  I could not copy and paste, as it would disappear when I tried.  But look at it under FAQ.

It seems to have been introduced in December 2013.  I am still leery, because they really pushed Trifexis as being the new ‘super’ flea/tick med and so many dogs (perhaps even Sadie, who knows – she was on it, but I had stopped months before she collapsed) became and are still becoming sick from the product.  I have heard, heard mind you, that there may be a recall on Trifexis.  Until it happens though, who knows.

I also read some reviews on 1-800-petmeds.  After reading ALL the reviews, I’m still not sure about using it.  Like I said, since it’s been out for about

In a well-controlled field study, NexGard was used concomitantly with other medications, such as vaccines, anthelmintics, antibiotics (including topicals), steroids, nonsteroidal anti-inflammatory drugs (NSAIDs), anesthetics, and antihistamines.

 

In a well-controlled field study, NexGard was used concomitantly with other medications, such as vaccines, anthelmintics, antibiotics (including topicals), steroids, nonsteroidal anti-inflammatory drugs (NSAIDs), anesthetics, and antihistamines.

Sadie’s vet is due to call today, so I will ask her about it and let you know her thoughts.  Anyone else know anything?  Wouldn’t it be wonderful if there IS a flea/tick preventative that our dogs could take.

Is Ollie still doing well on the gelatin and GLM’s?  Give both Worzel and Ollie huge hugs.  Love, Linda & Sadie

[admin]

Thanks Tamara – much appreciated! So price looks OK, actually – it’s all the tick/flea diseases we have here in France I was quoted for. Your PCR tests are very cheap compared to here. Interesting!

[admin]

Hi Linda

Thank you for that – yes it’s the Frontline lot – they also do Certifect which is more effective but cannot be used for some breeds as it can cross the blood-brain barrier, e.g. Border Collies. I have never used that either because of that fear. I have e-mailed the specialist on the NexGard  & am waiting for an answer – he is always a busy boy, so I won’t hold my breath! I would appreciate you asking your vet – any information is gratefully received. I saw the FDA licence was Sept 2013, so it’s fairly new over there too & it would be good if something actually was completely safe & worked for us all.

Ollie is doing well thanks, but is doesn’t like the gelatin in his food. I am ordering capsules next time to pop down his throat to save the subterfuge we have to do to hide it – he thinks we’re trying to poison him & is suspicious of his meals now!

Love & cuddles to you & the Birthday Girl

Sheena, Worzel & Fuss Pot xxxx

[Vally]

Linda, here the Trifexis is called Panoramis, so people here don’t even know there’s possibly a huge problem with it. Terrible.

[Vally]

Now Fuss Pot, mum is NOT trying to poison you.

Aren’t they funny.  I’m glad Bingo is a scoffer.  Will scoff anything and everything down (except zucchini).

Love Vally & Scoffer

[Patrice]

“NEXGARD kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis), and the treatment and control of American Dog tick (Dermacentor variabilis) infestations in dogs and puppies 8 weeks of age and older, weighing 4 pounds of body weight or greater, for one month.”

“Mode of Action:
Afoxolaner is a member of the isoxazoline family, shown to bind at a binding site to
inhibit insect and acarine ligand-gated chloride channels, in particular those gated
by the neurotransmitter gamma-aminobutyric acid (GABA), thereby blocking pre- and post-synaptic transfer of chloride ions across cell membranes. Prolonged afoxolaner-induced hyperexcitation results in uncontrolled activity of the central nervous system and death of insects and acarines. The selective toxicity of afoxolaner between insects and acarines and mammals may be inferred by the differential sensitivity of the insects and acarines’ GABA receptors versus mammalian GABA receptors.”
“Adverse Reactions:
In a well-controlled US field study, which included a total of 333 households and 615 treated dogs (415 administered afoxolaner; 200 administered active control), no serious adverse reactions were observed with NEXGARD.

Over the 90-day study period, all observations of potential adverse reactions were recorded. The most frequent reactions reported at an incidence of > 1% within any of the three months of observations are presented in the following table. The most frequently reported adverse reaction was vomiting. The occurrence of vomiting was generally self-limiting and of short duration and tended to decrease with subsequent doses in both groups. Five treated dogs experienced anorexia during the study, and two of those dogs experienced anorexia with the first dose but not subsequent doses”

“Use with caution in dogs with a history of seizures”

“A structurally unique isoxazoline class compound, A1443, exhibits antiparasitic activity against cat fleas and dog ticks comparable to that of the commercial ectoparasiticide fipronil. ”

Here are my thoughts. Nexgard is taken by mouth so that makes it systemic. So that is a big difference between it and the similar pesticide fipronil used in Frontline. Frontline works by distributing the pesticide in the oil glands of the skin and is not systemic.

Both pesticides act on neurotransmitters in fleas and ticks to cause nervous system disruption that leads to death. Pesticides of this nature are considered safe to mammals because their nervous systems are so different. However some breeds seem more sensitive because of a genetic difference. All vets should know which breeds these are and should exercise caution when prescribing this pesticide or any other.

While Nexgard claims it is effective against the American Dog Tick, that would, in a sense make it seem to be ineffective against the Deer Tick or the Lone Star Tick because  the literature does not mention them. Is this true or not? Is it possible they did not mention this because they didn’t test for these ticks? American Dog Ticks are now carrying some diseases but my fear where I live is the Deer Tick.  That’s the one that carries some nasty diseases.

Fleas are not life threatening, ticks can be. I am reluctant myself to put something inside my dog in order to get rid of fleas. I feel more comfortable putting Frontline on them and being vigilant about checking them.

I do use other protection that is extremely effective and safe. Permethrin is a  man-made derivative of Chrysanthemum flower extract that is impregnated into clothing fibers. It usually lasts through up to 70 washings. And before you ask, no it can’t weep onto the skin or into water. They have tested this significantly since it is used for American Military clothing and have found that the only way Permethrin leaves the clothing is via dryer lint. So both of us have head to toe ExOfficio clothing and I put big red bandannas on the dogs. Search for Doggles Insect Shield Bandana, but there are many brands.
my best
patrice