Bunny and Wendi

[admin]

Hi Bunny!  This is wonderful to read your post!!!  A PCV of 48 is awesome – way to go!  Best of luck with the upcoming results and you mentioned taking Wendi off the prednisone?  You’ll do that gradual right?  Please keep us posted when time allows.  We are always here for you and Wendi.

Love and hugs, Linda and Sadie

[Vally]

Hi Bunny, awesome news.  Well done Wendi. Yes good luck on the next lot of results.

Love Vally & Bingo.

[bunny & windi]

Has anybody heard of drugs causing IMAH. Wendi was on PROIN  for 2 months for incontinence before she  got sick.  I think that’s what caused it.       Bunny & Windi

[Tamara]

Hi Bunny, I’m new here and just reading about your Windi — I’m so happy to read how well she’s doing!

About meds causing IMHA — my vet questioned me closely about meds, and I’ve read that IMHA can be caused by certain meds.  Also, it’s possible that Windi had an unique reaction to that med that threw her into IMHA.  Our vet had two dogs when he was living in Texas, and they had scorpions everywhere that weren’t poisonous.  One of his dogs would pick them up and was stung, no problem other than pain and some swelling. The other dog got stung and was thrown into IMHA.  I still don’t know exactly what caused my Ashki’s.

Sending you and Windi best wishes and big hugs —

tamara and ashki xoxoxox

[admin]

Hi Bunny

I’ve had a look at PROIN (phenylpropanolamine hydrochloride) – it is a sympathomimetic amine closely related to ephedrine. It has been withdrawn for human use due to it causing haemorrhagic stroke, but is still used for incontinence in dogs as it does not have the same effect as it does on humans. It is FDA approved for use in dogs of course. Depending on the dose, it can increase blood pressure & decrease heart rate in dogs & I noted it can cause temporary (transient) elevations of platelet count, HCT , Hg & RBC count  and serum ALT. It also says use with caution in dogs with diabetes.

Have a look at http://www.prnpharmacal.com/pdfs/Proin-FullPackageLabel.pdf

“Changes to hematology and serum chemistry were not considered clinically significant or related to treatment. The most commonly reported side effects were: emesis, hypertension, anorexia, weight loss, proteinuria, and behavioral changes”

In the animal safety studies section it says:

“In a separate tolerance study, 6 healthy female Beagle dogs were administered PROIN at 20 mg/kg body weight (10 times the recommended dose) twice daily for 21 consecutive days. Mean systolic blood pressure was increased in the 10X group compared to the control, but mean values were within the normal range for both groups. Mean diastolic pressures were above the normal range on days 7 and 21 for the 10X group, and day 14 for the control. The 10X dogs had hypertensive mean MAP values on days 7 and 21, whereas the control dog mean MAP values were in the normal range. There was a trend in 10X dogs for lower heart rates following initiation of PPA treatment. Four of 6 dogs in the 10X group had heart rates below the normal range on day 7, whereas none of the control dogs did. The 10X group dogs had increased hematocrit, hemoglobin, RBC counts, urine specific gravity, and water intake consistent with transient, sub-clinical dehydration that occurred shortly after PPA treatment was started. All 6 dogs in the 10X group vomited at least once during the treatment period, whereas only 1 of the control dogs did. Most of the vomiting episodes took place within 1 hour of dosing. Mean platelet counts were also higher in 10X dogs on all 3 exam days; mean values were above the normal range on day 7, with individual values up to 1.5X ULN. The 10X group had a higher mean serum ALT value on day 7 than the control. Mean ALT values for both groups were in the normal range on all 3 exam days, but 2 dogs in the 10X group had ALT values up to 1.4X ULN on day 7; these elevated values were transient, and all dogs had normal ALT values on days 14 and 21. For either study, there was no evidence of chronic hypertension-induced target organ damage; there were no clinical findings attributable to PPA on the ophthalmic exams, electrocardiogram evaluation, or gross necropsy and histopathology.”

Please note that the dose was up to 10 times the recommended dose in that study. I hate reading animal research like this, but sadly this testing has to be done for FDA approval to be given.

I think you should report what has happened to Wendi to the FDA just in case the proin has some relevance – I presume you can do this via your Vet?  Even though there is no mention of AIHA/IMHA, there obviously is an effect on serum chemistry & you are right to be suspicious.

Hope this helps – keep on getting better & better Wendi!

All my best wishes, Sheena

[bunny & windi]

Sheena,       Wendi’s blood work was all normal. her red cells & white cells were all normal. she went off pred.monday. she has an  app. tomorrow for a insulin curve.      I will keep a  close eye on her.   I will say something about your letter. I feel in my heart that proin did this.   thanks for all your help ,   Bunny & Windi

[admin]

Hi Bunny

What wonderful news that Wendi’s tests are all normal – I am SO pleased! I would certainly avoid the Proin from now on too. Although it isn’t officially included in the list of drugs that are known to cause AIHA, you can never really be sure. Please let us know how things are going when you get a chance – I know you are a very busy lady. Good luck with the insulin curve testing – take care of yourself & the lovely Wendi

Love Sheena, Worzel & Ollie xxxx

[Vally]

Hey Bunny.  Fabulous news on Wendi’s tests.  She’s a very clever girl.  More good luck from me for the insulin test.

Love Vally & Bingo

[admin]

Hi Bunny!  This is wonderful to read your post!!!  A PCV of 48 is awesome – way to go!  Best of luck with the upcoming results and you mentioned taking Wendi off the prednisone?  You’ll do that gradual right?  Please keep us posted when time allows.  We are always here for you and Wendi.

Love and hugs, Linda and Sadie

[Vally]

Hi Bunny, awesome news.  Well done Wendi. Yes good luck on the next lot of results.

Love Vally & Bingo.

[bunny & windi]

Has anybody heard of drugs causing IMAH. Wendi was on PROIN  for 2 months for incontinence before she  got sick.  I think that’s what caused it.       Bunny & Windi

[Tamara]

Hi Bunny, I’m new here and just reading about your Windi — I’m so happy to read how well she’s doing!

About meds causing IMHA — my vet questioned me closely about meds, and I’ve read that IMHA can be caused by certain meds.  Also, it’s possible that Windi had an unique reaction to that med that threw her into IMHA.  Our vet had two dogs when he was living in Texas, and they had scorpions everywhere that weren’t poisonous.  One of his dogs would pick them up and was stung, no problem other than pain and some swelling. The other dog got stung and was thrown into IMHA.  I still don’t know exactly what caused my Ashki’s.

Sending you and Windi best wishes and big hugs —

tamara and ashki xoxoxox

[admin]

Hi Bunny

I’ve had a look at PROIN (phenylpropanolamine hydrochloride) – it is a sympathomimetic amine closely related to ephedrine. It has been withdrawn for human use due to it causing haemorrhagic stroke, but is still used for incontinence in dogs as it does not have the same effect as it does on humans. It is FDA approved for use in dogs of course. Depending on the dose, it can increase blood pressure & decrease heart rate in dogs & I noted it can cause temporary (transient) elevations of platelet count, HCT , Hg & RBC count  and serum ALT. It also says use with caution in dogs with diabetes.

Have a look at http://www.prnpharmacal.com/pdfs/Proin-FullPackageLabel.pdf

“Changes to hematology and serum chemistry were not considered clinically significant or related to treatment. The most commonly reported side effects were: emesis, hypertension, anorexia, weight loss, proteinuria, and behavioral changes”

In the animal safety studies section it says:

“In a separate tolerance study, 6 healthy female Beagle dogs were administered PROIN at 20 mg/kg body weight (10 times the recommended dose) twice daily for 21 consecutive days. Mean systolic blood pressure was increased in the 10X group compared to the control, but mean values were within the normal range for both groups. Mean diastolic pressures were above the normal range on days 7 and 21 for the 10X group, and day 14 for the control. The 10X dogs had hypertensive mean MAP values on days 7 and 21, whereas the control dog mean MAP values were in the normal range. There was a trend in 10X dogs for lower heart rates following initiation of PPA treatment. Four of 6 dogs in the 10X group had heart rates below the normal range on day 7, whereas none of the control dogs did. The 10X group dogs had increased hematocrit, hemoglobin, RBC counts, urine specific gravity, and water intake consistent with transient, sub-clinical dehydration that occurred shortly after PPA treatment was started. All 6 dogs in the 10X group vomited at least once during the treatment period, whereas only 1 of the control dogs did. Most of the vomiting episodes took place within 1 hour of dosing. Mean platelet counts were also higher in 10X dogs on all 3 exam days; mean values were above the normal range on day 7, with individual values up to 1.5X ULN. The 10X group had a higher mean serum ALT value on day 7 than the control. Mean ALT values for both groups were in the normal range on all 3 exam days, but 2 dogs in the 10X group had ALT values up to 1.4X ULN on day 7; these elevated values were transient, and all dogs had normal ALT values on days 14 and 21. For either study, there was no evidence of chronic hypertension-induced target organ damage; there were no clinical findings attributable to PPA on the ophthalmic exams, electrocardiogram evaluation, or gross necropsy and histopathology.”

Please note that the dose was up to 10 times the recommended dose in that study. I hate reading animal research like this, but sadly this testing has to be done for FDA approval to be given.

I think you should report what has happened to Wendi to the FDA just in case the proin has some relevance – I presume you can do this via your Vet?  Even though there is no mention of AIHA/IMHA, there obviously is an effect on serum chemistry & you are right to be suspicious.

Hope this helps – keep on getting better & better Wendi!

All my best wishes, Sheena

[bunny & windi]

Sheena,       Wendi’s blood work was all normal. her red cells & white cells were all normal. she went off pred.monday. she has an  app. tomorrow for a insulin curve.      I will keep a  close eye on her.   I will say something about your letter. I feel in my heart that proin did this.   thanks for all your help ,   Bunny & Windi

[admin]

Hi Bunny

What wonderful news that Wendi’s tests are all normal – I am SO pleased! I would certainly avoid the Proin from now on too. Although it isn’t officially included in the list of drugs that are known to cause AIHA, you can never really be sure. Please let us know how things are going when you get a chance – I know you are a very busy lady. Good luck with the insulin curve testing – take care of yourself & the lovely Wendi

Love Sheena, Worzel & Ollie xxxx

[Vally]

Hey Bunny.  Fabulous news on Wendi’s tests.  She’s a very clever girl.  More good luck from me for the insulin test.

Love Vally & Bingo