Sophie – Possible Relapse?

Sophie, a black and tan mini doxie, was diagnosed with IMHA at the end of March 2015. She was acting completely fine, we noticed that she peed blood and we took her in ASAP. She went to an emergency vet and stayed there for a week. She had multiple transfusions and finally started showing interest in food and stabilizing. They released her home to us and we began our recovery! An odd thing that happened (right after discharge) to her was that her ear tips/edges died and broke off – so she has notches in her ears now.

Sophie was always reactive to vaccines – she had a wierd ear thing before after her vaccines – all of her ear hair fell out and the edges got crusty. The vet told me to make sure to always pre-treat her with Benadryl before vaccinating, which I always did. Last spring she got fleas for the first time ever and the vet put her on Revolution. I believe that this is what triggered her IMHA.

She has been able to steadily reduce her meds – She was on 5ML Mycophenolate every other day and 1/4 tab of 5mg Prednisone on the alternating days – She is always on Plavix. Sophie’s PCV has gone up and up – it has been in the low 50’s for 6 months. She recently got off of Prednisone, approx one month ago. When she went in for her recheck yesterday the vet said she thinks she is relapsing/coming out of remission. Her reticulocites are low and her CBC shows funky lab values. Her CMP is all within normal ranges. The vet put her back up to 5mg Prednisone 2 times per day, 5ml Mycophenolate 2 times per day, continued Plavix. The vet also found some pyoderma on her belly and prescribed Simplicef for that.
Sophie is my child – I do everything for her, include work from home so I can take care of her and keep a close eye on her always. I do everything possible to keep her safe and this just kills me. She is lethargic and not as bright since starting all these meds back to starting doses. I am worried as usual – I think I should seek a thyroid analysis from Hemopet – any other recommendations?? Help!? Are we going overkill on the meds??