Rare hematological disease indicated by low numbers of circulating neutrophils. Causes can include an increased demand due to acute severe inflammation (infectious or non-infectious) with neutrophils moving from the circulating to the marginal and or tissue pools, immune-mediated destruction of circulating neutrophils, and decreased bone marrow production. Giant Schnauzers have a known breed predisposition. Minature Schnauzers may have splenomegaly. Less than 1% of all neutropenia cases in dogs are primary immune-mediated neutropenia. Secondary immune-mediated neutropenia can be due to hypoadrenocorticism, DIC, drugs, neoplasia, SLE and tick diseases. Bone marrow biopsy may show granulocytic hyperplasia. Treatment usually requires long-term therapy with broad-spectrum antimicrobials and low doses doses of prednisolone (1.2 mg/kg daily.) Higher doses of prednisolone may exacerbate underlying infections.
Second Chance Facts and Resources
Dr. Dodds: Lumps and Bumps, Iatrogenic Hyperadrenocorticism in Dogs, Images of Cushing’s Disease Skin Conditions
Liver Cleansing Diet, Nutrigenomics, Home Cooking and Protein For Seniors, Dogaware Nutritional Website.
Guidelines on How to Use Supplements Wisely, Information About Using Kelp in Canine Diets.
Canine Hypothyroidism: Dr. Karen Becker Interviews Dr. Dodds About The Hidden Signs of Hypothyroidism.
Dr. Dodds Video, 2016 Minimal and Non Core Vaccinations, Kennel Cough, Leptospirosis, Lyme, Influenza.